Overview

  • Product name
  • Description
    Rabbit polyclonal to SENP2
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    KTKRNSDLNLLEWTHHS

    , corresponding to amino acids 517-533 of Human SENP 2.

  • Positive control
    • HL60 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab3660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500.
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
  • Sequence similarities
    Belongs to the peptidase C48 family.
  • Domain
    The N-terminus is necessary and sufficient for nuclear envelope targeting.
  • Post-translational
    modifications
    Polyubiquitinated; which leads to proteasomal degradation.
  • Cellular localization
    Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Axam2 antibody
    • DKFZp762A2316 antibody
    • KIAA1331 antibody
    • Senp2 antibody
    • SENP2_HUMAN antibody
    • Sentrin specific protease 2 antibody
    • Sentrin-specific protease 2 antibody
    • Sentrin/SUMO specific protease SENP2 antibody
    • Sentrin/SUMO-specific protease SENP2 antibody
    • SMT3 specific isopeptidase 2 antibody
    • SMT3-specific isopeptidase 2 antibody
    • Smt3ip2 antibody
    • SUMO1/sentrin/SMT3 specific peptidase 2 antibody
    see all

Images

  • ab3660 at a 1/100 dilution staining approximately 68 kDa band of SENP2 in Jurkat cell lysate by Western blot (ECL).
  • ab3660 staining SENP2 in human breast carcinoma (BC) tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

References

This product has been referenced in:
  • Lu H  et al. The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation. Cell Cycle 13:3892-902 (2014). WB . Read more (PubMed: 25483061) »
  • Jones MC  et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A 103:16272-7 (2006). Read more (PubMed: 17053081) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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