Overview

  • Product name
  • Description
    Rabbit polyclonal to SENP2
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide containing a sequence corresponding to a region within N terminal amino acids 1 and 32 of Human SENP2 (NP_067640).

  • Positive control
    • A431, H1299, HepG2, Raji cell lysates. 293T and Molt-4 whole cell lysates. A431 cells and Cal27 xenograft.

Properties

Applications

Our Abpromise guarantee covers the use of ab96865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 68 kDa.
IHC-P 1/100 - 1/500.
ICC/IF 1/100 - 1/200.

Target

  • Function
    Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
  • Sequence similarities
    Belongs to the peptidase C48 family.
  • Domain
    The N-terminus is necessary and sufficient for nuclear envelope targeting.
  • Post-translational
    modifications
    Polyubiquitinated; which leads to proteasomal degradation.
  • Cellular localization
    Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Axam2 antibody
    • DKFZp762A2316 antibody
    • KIAA1331 antibody
    • Senp2 antibody
    • SENP2_HUMAN antibody
    • Sentrin specific protease 2 antibody
    • Sentrin-specific protease 2 antibody
    • Sentrin/SUMO specific protease SENP2 antibody
    • Sentrin/SUMO-specific protease SENP2 antibody
    • SMT3 specific isopeptidase 2 antibody
    • SMT3-specific isopeptidase 2 antibody
    • Smt3ip2 antibody
    • SUMO1/sentrin/SMT3 specific peptidase 2 antibody
    see all

Images

  • All lanes : Anti-SENP2 antibody (ab96865) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : MOLT-4 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 68 kDa
  • Immunofluorescence analysis of paraformaldehyde-fixed A431, using SENP2 antibody (ab96865) at 1/200 dilution. Lower image merged with DNA probe.
  • Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SENP2 antibody (ab96865) at 1/500 dilution.

References

ab96865 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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