Overview

  • Product name
    Anti-SENP2 antibody [EPR4356(2)]
    See all SENP2 primary antibodies
  • Description
    Rabbit monoclonal [EPR4356(2)] to SENP2
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
    Unsuitable for: Flow Cyt or IP
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    A synthetic peptide corresponding to residues in Human SENP2.

  • Positive control
    • MDA-MB-435, NIH:OVCAR-3, and 293T cell lysates; Human colon tissue.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab124724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC/IF 1/250 - 1/500.
  • Application notes
    Is unsuitable for Flow Cyt or IP.
  • Target

    • Function
      Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
    • Sequence similarities
      Belongs to the peptidase C48 family.
    • Domain
      The N-terminus is necessary and sufficient for nuclear envelope targeting.
    • Post-translational
      modifications
      Polyubiquitinated; which leads to proteasomal degradation.
    • Cellular localization
      Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Axam2 antibody
      • DKFZp762A2316 antibody
      • KIAA1331 antibody
      • Senp2 antibody
      • SENP2_HUMAN antibody
      • Sentrin specific protease 2 antibody
      • Sentrin-specific protease 2 antibody
      • Sentrin/SUMO specific protease SENP2 antibody
      • Sentrin/SUMO-specific protease SENP2 antibody
      • SMT3 specific isopeptidase 2 antibody
      • SMT3-specific isopeptidase 2 antibody
      • Smt3ip2 antibody
      • SUMO1/sentrin/SMT3 specific peptidase 2 antibody
      see all

    Images

    • ab124724, at 1/500 dilution, staining SENP2 in paraffin embedded Human colon tissue by immunohistochemistry.
    • All lanes : Anti-SENP2 antibody [EPR4356(2)] (ab124724) at 1/10000 dilution

      Lane 1 : MDA-MB-435 cell lysate
      Lane 2 : NIH:OVCAR-3 cell lysate
      Lane 3 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 68 kDa

    References

    This product has been referenced in:

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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