Overview

  • Product nameAnti-SENP3 antibody - Aminoterminal end
    See all SENP3 primary antibodies
  • Description
    Rabbit polyclonal to SENP3 - Aminoterminal end
  • Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH-conjugated synthetic peptide, from the N-terminal region of Human SENP3

  • Positive control
    • Saos-2 cell lysate; Human breast carcinoma tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesThe antibody was purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab71677 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 65 kDa.
IHC-P 1/50 - 1/100.

Target

  • FunctionProtease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
  • Sequence similaritiesBelongs to the peptidase C48 family.
  • Cellular localizationCytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
  • Information by UniProt
  • Database links
  • Alternative names
    • SENP3 antibody
    • SENP3_HUMAN antibody
    • Sentrin / SUMO specific protease 3 antibody
    • Sentrin specific protease 3 antibody
    • Sentrin-specific protease 3 antibody
    • Sentrin/SUMO-specific protease SENP3 antibody
    • SMT3IP1 antibody
    • SSP3 antibody
    • SUMO 1 specific protease 3 antibody
    • SUMO-1-specific protease 3 antibody
    • SUMO1 specific protease 3 antibody
    • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
    • SUSP3 antibody
    see all

Anti-SENP3 antibody - Aminoterminal end images

  • Anti-SENP3 antibody - Aminoterminal end (ab71677) at 1/100 dilution + Saos-2 cell lysate at 12.5 µg

    Predicted band size : 65 kDa
    Observed band size : 65 kDa
  • Analysis of SENP3 expression on formalin-fixed and paraffin-embedded human breast carcinoma tissue using 1:50 ab71677 (peroxidase-conjugated secondary antibody, AEC staining).

References for Anti-SENP3 antibody - Aminoterminal end (ab71677)

This product has been referenced in:
  • Sun Z  et al. Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Oncol Rep 29:1701-6 (2013). WB, IHC-P ; Human . Read more (PubMed: 23467634) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"