Overview

  • Product nameAnti-SENP3 antibody [EP4360]
    See all SENP3 primary antibodies
  • Description
    Rabbit monoclonal [EP4360] to SENP3
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to residues near the C terminus of Human SENP3.

  • Positive control
    • MCF-7, Jurkat and HeLa cell lysates.
  • General notes

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • PurityTissue culture supernatant
  • ClonalityMonoclonal
  • Clone numberEP4360
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 65 kDa.
  • Application notesIs unsuitable for Flow Cyt,ICC,IHC-P or IP.
  • Target

    • FunctionProtease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
    • Sequence similaritiesBelongs to the peptidase C48 family.
    • Cellular localizationCytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
    • Information by UniProt
    • Database links
    • Alternative names
      • SENP3 antibody
      • SENP3_HUMAN antibody
      • Sentrin / SUMO specific protease 3 antibody
      • Sentrin specific protease 3 antibody
      • Sentrin-specific protease 3 antibody
      • Sentrin/SUMO-specific protease SENP3 antibody
      • SMT3IP1 antibody
      • SSP3 antibody
      • SUMO 1 specific protease 3 antibody
      • SUMO-1-specific protease 3 antibody
      • SUMO1 specific protease 3 antibody
      • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
      • SUSP3 antibody
      see all

    Anti-SENP3 antibody [EP4360] images

    • All lanes : Anti-SENP3 antibody [EP4360] (ab124790) at 1/1000 dilution

      Lane 1 : MCF-7 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 65 kDa

    References for Anti-SENP3 antibody [EP4360] (ab124790)

    ab124790 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab124790.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"