Overview

  • Product nameAnti-SENP6 antibody
    See all SENP6 primary antibodies
  • Description
    Mouse monoclonal to SENP6
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-111 of Human SENP6

Properties

Applications

Our Abpromise guarantee covers the use of ab57239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProtease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
    • Tissue specificityHighly expressed in reproductive organs, such as testis, ovary and prostate.
    • PathwayProtein modification; protein sumoylation.
    • Sequence similaritiesBelongs to the peptidase C48 family.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2810017C20Rik antibody
      • FLJ11355 antibody
      • FLJ11887 antibody
      • KIAA0389 antibody
      • KIAA0797 antibody
      • SENP 6 antibody
      • Senp6 antibody
      • SENP6_HUMAN antibody
      • Sentrin specific protease 6 antibody
      • Sentrin-specific protease 6 antibody
      • Sentrin/SUMO specific protease SENP6 antibody
      • Sentrin/SUMO-specific protease SENP6 antibody
      • SSP 1 antibody
      • SSP1 antibody
      • SUMO 1 specific protease 1 antibody
      • SUMO 1 specific protease antibody
      • SUMO-1-specific protease 1 antibody
      • SUMO1 specific protease 1 antibody
      • SUMO1 specific protease antibody
      • SUMO1/sentrin specific peptidase 6 antibody
      • SUSP 1 antibody
      • SUSP1 antibody
      see all

    Anti-SENP6 antibody images

    • SENP6 antibody (ab57239) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human stomach.


    • Predicted band size : 126 kDa
      SENP6 antibody (ab57239) at 1ug/lane + IMR-32 cell lysate at 25ug/lane.

    References for Anti-SENP6 antibody (ab57239)

    ab57239 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57239.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"