Overview

  • Product nameAnti-SENP6 antibody
    See all SENP6 primary antibodies
  • Description
    Goat polyclonal to SENP6
  • Specificityab77619 is expected to recognise both reported isoforms (NP_001093879.1; NP_056386.2).
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Cow, Dog, Chimpanzee, Rhesus monkey
  • Immunogen

    Synthetic peptide:

    C-KPKYEPNPHYHEN

    , corresponding to internal sequence amino acids 778-790 of Human SENP6 (NP_056386.2).

  • Positive control
    • HeLa cell nuclear lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab77619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 150 kDa (predicted molecular weight: 126 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionProtease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
    • Tissue specificityHighly expressed in reproductive organs, such as testis, ovary and prostate.
    • PathwayProtein modification; protein sumoylation.
    • Sequence similaritiesBelongs to the peptidase C48 family.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2810017C20Rik antibody
      • FLJ11355 antibody
      • FLJ11887 antibody
      • KIAA0389 antibody
      • KIAA0797 antibody
      • SENP 6 antibody
      • Senp6 antibody
      • SENP6_HUMAN antibody
      • Sentrin specific protease 6 antibody
      • Sentrin-specific protease 6 antibody
      • Sentrin/SUMO specific protease SENP6 antibody
      • Sentrin/SUMO-specific protease SENP6 antibody
      • SSP 1 antibody
      • SSP1 antibody
      • SUMO 1 specific protease 1 antibody
      • SUMO 1 specific protease antibody
      • SUMO-1-specific protease 1 antibody
      • SUMO1 specific protease 1 antibody
      • SUMO1 specific protease antibody
      • SUMO1/sentrin specific peptidase 6 antibody
      • SUSP 1 antibody
      • SUSP1 antibody
      see all

    Anti-SENP6 antibody images

    References for Anti-SENP6 antibody (ab77619)

    ab77619 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab77619.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"