Anti-SENP6 antibody - Carboxyterminal end (ab59899)

Overview

  • Product name
    Anti-SENP6 antibody - Carboxyterminal end
    See all SENP6 primary antibodies
  • Description
    Rabbit polyclonal to SENP6 - Carboxyterminal end
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide selected from the C-terminal region of human SENP6 conjugated to KLH.

  • Positive control
    • HL60 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab59899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 126 kDa (predicted molecular weight: 126 kDa).
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
  • Tissue specificity
    Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • Pathway
    Protein modification; protein sumoylation.
  • Sequence similarities
    Belongs to the peptidase C48 family.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2810017C20Rik antibody
    • FLJ11355 antibody
    • FLJ11887 antibody
    • KIAA0389 antibody
    • KIAA0797 antibody
    • SENP 6 antibody
    • Senp6 antibody
    • SENP6_HUMAN antibody
    • Sentrin specific protease 6 antibody
    • Sentrin-specific protease 6 antibody
    • Sentrin/SUMO specific protease SENP6 antibody
    • Sentrin/SUMO-specific protease SENP6 antibody
    • SSP 1 antibody
    • SSP1 antibody
    • SUMO 1 specific protease 1 antibody
    • SUMO 1 specific protease antibody
    • SUMO-1-specific protease 1 antibody
    • SUMO1 specific protease 1 antibody
    • SUMO1 specific protease antibody
    • SUMO1/sentrin specific peptidase 6 antibody
    • SUSP 1 antibody
    • SUSP1 antibody
    see all

Images

  • Anti-SENP6 antibody - Carboxyterminal end (ab59899) at 1/100 dilution + HL60 cell lysate

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 126 kDa
    Observed band size : 126 kDa
  • ab59899 at 1/100 dilution staining SENP6 in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. A peroxidase-conjugated secondary antibody was used followed by AEC staining.

References

ab59899 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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