Human Predicted to work with:
Recombinant fragment: NSFFHYDSHS RSNSVHAKQV AEKLEAFLGR KGDKLAFVEE KAPAQQNSYD CGMYVICNTE ALCQNFFRQQ TESLLQLLTP AYITKKRGEW KDLIATLAKK, corresponding to amino acids 113 - 212 of human SENP8 (NP_660205) with a tag
FunctionProtease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.
Tissue specificityBroadly expressed, with highest levels in kidney and pancreas.
Sequence similaritiesBelongs to the peptidase C48 family.