Overview

  • Product name
  • Description
    Rabbit polyclonal to SEPN1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 507-557 (NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP) of Human SEPN1 (NP_996809)

  • Positive control
    • HepG2 Cell Lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 2% Sucrose, 1X PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab105943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Tissue specificity
    Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach.
  • Involvement in disease
    Defects in SEPN1 are the cause of myopathy SEPN1-related (M-SEPN1) [MIM:602771]. A group of neuromuscular disorders consisting of four nosological entities: classic multiminicore disease (MmD), rigid spine muscular dystrophy 1 syndrome (RSMD1), desmin-related myopathy with Mallory body-like inclusions (MB-DRM) and congenital fiber-type disproportion. All are clinically characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure.
  • Sequence similarities
    Contains 1 EF-hand domain.
  • Domain
    The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.
  • Post-translational
    modifications
    N-glycosylated (isoform 2).
  • Cellular localization
    Endoplasmic reticulum membrane. Probably membrane-associated.
  • Information by UniProt
  • Database links
  • Alternative names
    • CFTD antibody
    • MDRS1 antibody
    • RSMD1 antibody
    • RSS antibody
    • Selenoprotein N antibody
    • Selenoprotein N, 1 antibody
    • SelN antibody
    • SELN_HUMAN antibody
    • sepn1 antibody
    see all

Anti-SEPN1 antibody images

  • Anti-SEPN1 antibody (ab105943) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 58 kDa

References for Anti-SEPN1 antibody (ab105943)

ab105943 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab105943.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up