• Product name
  • Description
    Mouse monoclonal to SERBP1
  • Tested applications
    Suitable for: WB, ICC/IF, Flow Cytmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-403 of Human SERBP1

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. We would recommend antibody ab55993 as a replacement.



Our Abpromise guarantee covers the use of ab57285 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 45 kDa.
ICC/IF Use a concentration of 10 µg/ml.
Flow Cyt Use 1µg for 106 cells. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.


  • Function
    May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay.
  • Tissue specificity
    Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
  • Cellular localization
    Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Also found in perinuclear regions.
  • Information by UniProt
  • Database links
  • Alternative names
    • CGI 55 antibody
    • CHD3IP antibody
    • Chromodomain helicase DNA binding protein 3 interacting protein antibody
    • DKFZp564M2423 antibody
    • FLJ90489 antibody
    • HABP4L antibody
    • PAI 1 mRNA binding protein antibody
    • PAI RBP1 antibody
    • PAI-RBP1 antibody
    • PAI1 RNA-binding protein 1 antibody
    • PAIRB_HUMAN antibody
    • PAIRBP1 antibody
    • Plasminogen activator inhibitor 1 RNA binding protein antibody
    • Plasminogen activator inhibitor 1 RNA-binding protein antibody
    • Serbp1 antibody
    • SERPINE1 mRNA binding protein 1 antibody
    • SERPINE1 mRNA-binding protein 1 antibody
    see all


  • SERBP1 antibody (ab57285) used in immunofluorescence at 10ug/ml on HeLa cells.

  • Predicted band size : 45 kDa
    SERBP1 antibody (ab57285) at 1ug/lane + HeLa cell lysate at 25ug/lane.
  • Overlay histogram showing HEK293 cells stained with ab57285 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab57285, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in HEK293 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.


This product has been referenced in:
  • Peluso JJ  et al. Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the viability of spontaneously immortalized granulosa cells and rat granulosa cells. Biol Reprod 88:20 (2013). WB, ICC/IF ; Rat . Read more (PubMed: 23242527) »
  • Heberlein KR  et al. A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction. Arterioscler Thromb Vasc Biol 32:1271-9 (2012). ICC/IF ; Human . Read more (PubMed: 22383705) »

See all 2 Publications for this product

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