Overview

  • Product nameAnti-Serglycin antibody
    See all Serglycin primary antibodies
  • Description
    Rabbit polyclonal to Serglycin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 5-54 (LLKCSRLVLA LALILVLESS VQGYPTRRAR YQWVRCNPDS NSANCLEEKG) of Human SRGN (NP_002718).

  • Positive control
    • Jurkat cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab123051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 18 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionPlays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • Sequence similaritiesBelongs to the serglycin family.
  • Post-translational
    modifications
    O-glcosylated; contains chondroitin sulfate and heparan sulfate.
  • Cellular localizationCytoplasmic granule. Secreted > extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.
  • Information by UniProt
  • Database links
  • Alternative names
    • Chondroitin sulfate proteoglycan core protein antibody
    • Cytolytic granule proteoglycan core protein antibody
    • FLJ12930 antibody
    • gp600 antibody
    • Hematopoetic proteoglycan core protein antibody
    • Mastocytoma proteoglycan core protein antibody
    • MGC9289 antibody
    • OTTHUMP00000019716 antibody
    • P.PG antibody
    • PG19 core protein antibody
    • Pgsg antibody
    • Platelet proteoglycan core protein antibody
    • platelet proteoglycan protein core antibody
    • PLATELET PROTEOGLYCAN PROTEIN CORE; PPG antibody
    • PPG antibody
    • PRG antibody
    • PRG1 antibody
    • PROTEOGLYCAN 1 antibody
    • proteoglycan 1, secretory granule antibody
    • Proteoglycan 10K core protein antibody
    • Proteoglycan peptide core protein antibody
    • PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE antibody
    • secretory granule proteoglycan 1 antibody
    • Secretory granule proteoglycan core peptide antibody
    • Secretory granule proteoglycan core protein antibody
    • Serglycin antibody
    • serglycin proteoglycan antibody
    • Sgc antibody
    • Srgn antibody
    • SRGN_HUMAN antibody
    see all

Anti-Serglycin antibody images

  • Anti-Serglycin antibody (ab123051) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 18 kDa

References for Anti-Serglycin antibody (ab123051)

ab123051 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab123051.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"