Anti-Serine/threonine-protein kinase 4 antibody (ab25136)

Overview

  • Product name
    Anti-Serine/threonine-protein kinase 4 antibody
    See all Serine/threonine-protein kinase 4 primary antibodies
  • Description
    Rabbit polyclonal to Serine/threonine-protein kinase 4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Serine/threonine-protein kinase 4 (N terminal).
    (Peptide available as ab51929)

Properties

Applications

Our Abpromise guarantee covers the use of ab25136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 1 - 4 µg/ml. Predicted molecular weight: 56 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation.
    • Tissue specificity
      Ubiquitously expressed.
    • Sequence similarities
      Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
      Contains 1 protein kinase domain.
      Contains 1 SARAH domain.
    • Post-translational
      modifications
      Autophosphorylated on serine and threonine residues.
    • Cellular localization
      Cytoplasm. Nucleus. The caspase-cleaved form cycles between the nucleus and cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Kinase responsive to stress antibody
      • Krs2 antibody
      • Mammalian STE20 like protein kinase 1 antibody
      • Mammalian STE20-like protein kinase 1 antibody
      • Mammalian sterile 20 like 1 antibody
      • MST-1 antibody
      • MST1 antibody
      • Serine/threonine kinase 4 antibody
      • Serine/threonine protein kinase Krs 2 antibody
      • Serine/threonine-protein kinase 4 antibody
      • Serine/threonine-protein kinase Krs-2 antibody
      • STE20 like kinase MST1 antibody
      • STE20-like kinase MST1 antibody
      • STK4 antibody
      • STK4_HUMAN antibody
      • TIIAC antibody
      • YSK3 antibody
      see all

    References

    ab25136 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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