Serotonin N-acetyltransferase peptide (ab4975)

Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab4975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Phospho-Thr29 AA-NAT, catalog ab3439. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • AA-NAT
    • Aanat
    • Aralkylamine N-acetyltransferase
    • Arylalkylamine N acetyltransferase
    • Serotonin acetylase
    • Serotonin N-acetyltransferase
    • SNAT
    • SNAT_HUMAN
    see all
  • FunctionControls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
  • Tissue specificityHighly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
  • PathwayAromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
  • Involvement in diseaseDelayed sleep phase syndrome
  • Sequence similaritiesBelongs to the acetyltransferase family. AANAT subfamily.
    Contains 1 N-acetyltransferase domain.
  • Post-translational
    modifications
    cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Serotonin N-acetyltransferase peptide (ab4975)

ab4975 has not yet been referenced specifically in any publications.

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