Serotonin N-acetyltransferase peptide (ab5004)

Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and AA-NAT, catalog ab3506. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • AA-NAT
    • Aanat
    • Aralkylamine N-acetyltransferase
    • Arylalkylamine N acetyltransferase
    • Serotonin acetylase
    • Serotonin N-acetyltransferase
    • SNAT
    • SNAT_HUMAN
    see all
  • FunctionControls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
  • Tissue specificityHighly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
  • PathwayAromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
  • Involvement in diseaseDelayed sleep phase syndrome
  • Sequence similaritiesBelongs to the acetyltransferase family. AANAT subfamily.
    Contains 1 N-acetyltransferase domain.
  • Post-translational
    modifications
    cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Serotonin N-acetyltransferase peptide (ab5004)

ab5004 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab5004.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"