The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
5 hydroxytryptamine (serotonin) transporter
5 hydroxytryptamine transporter
Na+/Cl- dependent serotonin transporter
Serotonin transporter 1
Sodium dependent serotonin transporter
Sodium-dependent serotonin transporter
Solute carrier family 6 (neurotransmitter transporter) member 4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Solute carrier family 6 member 4
FunctionSerotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Tissue specificityExpressed in platelets (at protein level).
Sequence similaritiesBelongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
Post-translational modificationsGlycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms. Phosphorylated at Ser-611, Thr-613 and Thr-616.
Cellular localizationCell membrane. Endomembrane system. Endosome membrane. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.