Serotonin transporter peptide (74-84) (ab45727)

Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-LHQGERETWGK
    • Amino acids
      74 to 84

Specifications

Our Abpromise guarantee covers the use of ab45727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • 5 HTT
    • 5 HTTLPR
    • 5 hydroxytryptamine (serotonin) transporter
    • 5 hydroxytryptamine transporter
    • 5HT transporter
    • 5HTT
    • hSERT
    • HTT
    • Na+/Cl- dependent serotonin transporter
    • OCD1
    • SC6A4_HUMAN
    • Serotonin transporter 1
    • SERT
    • SERT1
    • Slc6a4
    • Sodium dependent serotonin transporter
    • Sodium-dependent serotonin transporter
    • Solute carrier family 6 (neurotransmitter transporter) member 4
    • solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
    • Solute carrier family 6 member 4
    see all
  • Function
    Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
  • Tissue specificity
    Expressed in platelets (at protein level).
  • Sequence similarities
    Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.
  • Post-translational
    modifications
    Glycosylated; modification with sialylated N-glycans is a requirement for transporters to associate with each other and to function as homooligomeric forms.
    Phosphorylated at Ser-611, Thr-613 and Thr-616.
  • Cellular localization
    Cell membrane. Endomembrane system. Endosome membrane. Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.
  • Information by UniProt

References

ab45727 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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