Overview

  • Product nameAnti-SerpinB6 antibody
    See all SerpinB6 primary antibodies
  • Description
    Goat polyclonal to SerpinB6
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cynomolgus Monkey, Orangutan
  • Immunogen

    Synthetic peptide:

    NWDEQFDKENTEER

    (Human) from the internal region of the protein sequence according to NP_004559.4.

  • Positive control
    • Human ovary lysates

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab77372 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: Antibody detection limit dilution 1/128000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
    • Tissue specificityExpressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
    • Involvement in diseaseDefects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
    • Sequence similaritiesBelongs to the serpin family. Ov-serpin subfamily.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAP antibody
      • Cytoplasmic antiproteinase antibody
      • Peptidase inhibitor 6 antibody
      • PI-6 antibody
      • PI6 antibody
      • Placental thrombin inhibitor antibody
      • Protease inhibitor 6 (placental thrombin inhibitor) antibody
      • PTI antibody
      • Serpin B6 antibody
      • SERPINB6 antibody
      • SPB6_HUMAN antibody
      see all

    Anti-SerpinB6 antibody images

    • Anti-SerpinB6 antibody (ab77372) at 0.1 µg/ml + human ovary lysate in RIPA buffer at 35 µg
      Developed using the ECL technique

      Predicted band size : 42 kDa
      Observed band size : 42 kDa

    References for Anti-SerpinB6 antibody (ab77372)

    ab77372 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab77372.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"