• Product nameAnti-SerpinB6 antibody [OTI2F8]
    See all SerpinB6 primary antibodies
  • Description
    Mouse monoclonal [OTI2F8] to SerpinB6
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein of Human SerpinB6 produced in HEK293T cells (NP_004559).

  • Positive control
    • HEK293T cells transfected with SerpinB6, Carcinoma of Human kidney, Adenocarcinoma of Human endometrium and Carcinoma of Human bladder tissues
  • General notes

    Dilute in PBS (pH7.3) before use.

    The clone number has been updated from 2F8 to OTI2F8, both clone numbers name the same clone.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 48% PBS, 1% BSA, 50% Glycerol
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityMonoclonal
  • Clone numberOTI2F8
  • IsotypeIgG2a
  • Research areas


Our Abpromise guarantee covers the use of ab119393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 43 kDa.
IHC-P 1/150.


  • FunctionMay be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
  • Tissue specificityExpressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.
  • Involvement in diseaseDefects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91) [MIM:613453]. It is a form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.
  • Sequence similaritiesBelongs to the serpin family. Ov-serpin subfamily.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAP antibody
    • Cytoplasmic antiproteinase antibody
    • Peptidase inhibitor 6 antibody
    • PI-6 antibody
    • PI6 antibody
    • Placental thrombin inhibitor antibody
    • Protease inhibitor 6 (placental thrombin inhibitor) antibody
    • PTI antibody
    • Serpin B6 antibody
    • SERPINB6 antibody
    • SPB6_HUMAN antibody
    see all

Anti-SerpinB6 antibody [OTI2F8] images

  • All lanes : Anti-SerpinB6 antibody [OTI2F8] (ab119393) at 1/500 dilution

    Lane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control
    Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SerpinB6

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 43 kDa
    HEK293T cell lysates were generated from transient transfection of the cDNA clone (RC203822)
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using ab119393 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using ab119393 at a dilution of 1/150.
  • Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using ab119393 at a dilution of 1/150.

References for Anti-SerpinB6 antibody [OTI2F8] (ab119393)

ab119393 has not yet been referenced specifically in any publications.

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