Overview

  • Product nameAnti-Serum Amyloid A antibody [291]
    See all Serum Amyloid A primary antibodies
  • Description
    Mouse monoclonal [291] to Serum Amyloid A
  • SpecificityReacts with recombinant human SAA. Does not cross-react with other human cytokines or growth factors tested such as IL1ß, IL8, MCAF, TGFß and EGF.
  • Tested applicationsSuitable for: IP, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

  • Positive control
    • 100ng/lane of recombinant protein

Properties

Applications

Our Abpromise guarantee covers the use of ab18713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent dilution.
WB Use a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa).

Target

  • FunctionMajor acute phase reactant. Apolipoprotein of the HDL complex.
  • Tissue specificityExpressed by the liver; secreted in plasma.
  • Involvement in diseaseNote=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
    Note=Elevated serum SSA protein levels may be associated with lung cancer.
  • Sequence similaritiesBelongs to the SAA family.
  • Post-translational
    modifications
    This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amyloid fibril protein AA antibody
    • Amyloid fibrils antibody
    • Amyloid protein A antibody
    • Fibrils antibody
    • MGC111216 antibody
    • OC antibody
    • PIG 4 antibody
    • PIG4 antibody
    • SAA 1 antibody
    • SAA 2 antibody
    • SAA antibody
    • SAA_HUMAN antibody
    • SAA1 antibody
    • SAA2 antibody
    • Serum amyloid A protein precursor antibody
    • Serum amyloid A1 isoform 1 antibody
    • Serum amyloid A1 isoform 2 antibody
    • Serum amyloid protein A(4-101) antibody
    • TP53I4 antibody
    • Tumor protein p53 inducible protein 4 antibody
    see all

References for Anti-Serum Amyloid A antibody [291] (ab18713)

This product has been referenced in:
  • Wood SL  et al. Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer. Br J Cancer 103:101-11 (2010). WB, IP ; Human . Read more (PubMed: 20531413) »
  • de Seny D  et al. Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis. Clin Chem : (2008). Read more (PubMed: 18436720) »

See all 2 Publications for this product

Product Wall

Blocking

Inconclusive
Abreviews
Application Blocking
Sample Human Serum (monocytic cells)
Specification monocytic cells
Username

Abcam user community

Verified customer

Submitted Jun 13 2013

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunoprecipitation
Sample Human Tissue lysate - other (Human Serum)
Total protein in input 500 µg
Specification Human Serum
Immuno-precipitation step Other - Protein-G DynaL
Username

Abcam user community

Verified customer

Submitted Jun 28 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"