Overview

  • Product name
    Anti-Serum Amyloid A antibody [291]
    See all Serum Amyloid A primary antibodies
  • Description
    Mouse monoclonal [291] to Serum Amyloid A
  • Specificity
    Reacts with recombinant human SAA. Does not cross-react with other human cytokines or growth factors tested such as IL1ß, IL8, MCAF, TGFß and EGF.
  • Tested applications
    Suitable for: IP, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

  • Positive control
    • 100ng/lane of recombinant protein
  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab18713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
ELISA Use at an assay dependent dilution.
WB Use a concentration of 0.1 - 0.5 µg/ml. Detects a band of approximately 12 kDa (predicted molecular weight: 14 kDa).

Target

  • Function
    Major acute phase reactant. Apolipoprotein of the HDL complex.
  • Tissue specificity
    Expressed by the liver; secreted in plasma.
  • Involvement in disease
    Note=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
    Note=Elevated serum SSA protein levels may be associated with lung cancer.
  • Sequence similarities
    Belongs to the SAA family.
  • Post-translational
    modifications
    This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amyloid fibril protein AA antibody
    • Amyloid fibrils antibody
    • Amyloid protein A antibody
    • Fibrils antibody
    • MGC111216 antibody
    • OC antibody
    • PIG 4 antibody
    • PIG4 antibody
    • SAA 1 antibody
    • SAA 2 antibody
    • SAA antibody
    • SAA_HUMAN antibody
    • SAA1 antibody
    • SAA2 antibody
    • Serum amyloid A protein precursor antibody
    • Serum amyloid A1 isoform 1 antibody
    • Serum amyloid A1 isoform 2 antibody
    • Serum amyloid protein A(4-101) antibody
    • TP53I4 antibody
    • Tumor protein p53 inducible protein 4 antibody
    see all

References

This product has been referenced in:
  • Wood SL  et al. Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer. Br J Cancer 103:101-11 (2010). WB, IP ; Human . Read more (PubMed: 20531413) »
  • de Seny D  et al. Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis. Clin Chem : (2008). Read more (PubMed: 18436720) »

See all 2 Publications for this product

Customer reviews and Q&As

Blocking

Inconclusive
Abreviews
Application
Blocking
Sample
Human Serum (monocytic cells)
Specification
monocytic cells
Username

Abcam user community

Verified customer

Submitted Jun 13 2013

Abcam guarantees this product to work in the species/application used in this Abreview.
Application
Immunoprecipitation
Sample
Human Tissue lysate - other (Human Serum)
Total protein in input
500 µg
Specification
Human Serum
Immuno-precipitation step
Other - Protein-G DynaL
Username

Abcam user community

Verified customer

Submitted Jun 28 2011

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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