Overview

  • Product nameAnti-Serum Amyloid A antibody [Reu-86.2]
    See all Serum Amyloid A primary antibodies
  • Description
    Mouse monoclonal [Reu-86.2] to Serum Amyloid A
  • SpecificityThe antibody reacts with AA-type Amyloid depositions.
  • Tested applicationsSuitable for: IHC-Fr, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human serum Amyloid A (Apo-SAA).

  • Positive control
    • Amyloid depositions (renal biopsy).
  • General notes


    Amyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • PurityTissue culture supernatant
  • Primary antibody notesAmyloidosis includes a family of diseases which have in common the extracellular deposition of ß-pleated fibrillar protein. Amyloidosis associated with chronic inflammatory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type.
  • ClonalityMonoclonal
  • Clone numberReu-86.2
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab8057 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionMajor acute phase reactant. Apolipoprotein of the HDL complex.
  • Tissue specificityExpressed by the liver; secreted in plasma.
  • Involvement in diseaseNote=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
    Note=Elevated serum SSA protein levels may be associated with lung cancer.
  • Sequence similaritiesBelongs to the SAA family.
  • Post-translational
    modifications
    This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amyloid fibril protein AA antibody
    • Amyloid fibrils antibody
    • Amyloid protein A antibody
    • Fibrils antibody
    • MGC111216 antibody
    • OC antibody
    • PIG 4 antibody
    • PIG4 antibody
    • SAA 1 antibody
    • SAA 2 antibody
    • SAA antibody
    • SAA_HUMAN antibody
    • SAA1 antibody
    • SAA2 antibody
    • Serum amyloid A protein precursor antibody
    • Serum amyloid A1 isoform 1 antibody
    • Serum amyloid A1 isoform 2 antibody
    • Serum amyloid protein A(4-101) antibody
    • TP53I4 antibody
    • Tumor protein p53 inducible protein 4 antibody
    see all

References for Anti-Serum Amyloid A antibody [Reu-86.2] (ab8057)

This product has been referenced in:
  • Hazenberg BPC (Natvig JB Eds.) et al. Detection of Amyloid AA in rectal biopsies with a new monoclonal anti-human SAA antibody (Reu 86.2). Amyloid and Amyloidosis :809-812 (1991). Read more (PubMed: ) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"