The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 5 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa). Block using 3% milk.
FunctionCan interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
Tissue specificityFound in serum and urine.
Involvement in diseaseNote=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
Sequence similaritiesBelongs to the pentaxin family. Contains 1 pentaxin domain.
Post-translational modificationsN-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected (PubMed:15174148).