Overview

  • Product nameSEW 2871
  • Description
    Potent, selective S1P1 agonist
  • Biological descriptionPotent, selective sphingosine-1-phosphate (S1P1) agonist (EC50 = 13 nM). Does not activate S1P2, S1P3, S1P4 or S1P5 receptors. Cell-permeable and active in vivo.
  • Purity> 98%

Properties

  • Chemical name5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
  • Molecular weight440.36
  • Chemical structureChemical Structure
  • Molecular formulaC20H10F6N2OS
  • CAS Number256414-75-2
  • PubChem identifier4077460
  • Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 20 mM and in ethanol to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESFC(F)(F)c2sc(cc2c1ccccc1)c3nc(no3)c4cccc(c4)C(F)(F)F
  • Source

    Synthetic

  • Research areas

    References for SEW 2871 (ab120983)

    This product has been referenced in:
    • Chi XX & Nicol GD The sphingosine 1-phosphate receptor, S1PR1, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. J Neurophysiol 104:2741-8 (2010). Read more (PubMed: 20844107) »
    • Tsukada YT  et al. S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias. J Cardiovasc Pharmacol 50:660-9 (2007). Read more (PubMed: 18091583) »
    • Bolick DT  et al. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler Thromb Vasc Biol 25:976-81 (2005). Read more (PubMed: 15761190) »
    • Sanna MG  et al. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem 279:13839-48 (2004). Read more (PubMed: 14732717) »

    See 0 Publications for this product

    Product Wall



    Our chemistry team have confirmed that we are not aware of any stability issues, although we haven’t tested it at elevated temperature. Literature melting point data suggests that it is stable at 95°C without any effect on its compo...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"