Anti-Sez6 antibody (ab121347)
Key features and details
- Rabbit polyclonal to Sez6
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Sez6 antibody
See all Sez6 primary antibodies -
Description
Rabbit polyclonal to Sez6 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Cow -
Immunogen
Recombinant fragment corresponding to amino acids 774-897 of Human Sez6 (UniProt: Q53EL9).
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Positive control
- Human hippocampus tissue and plasma.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab121347 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (1) |
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity. -
Sequence similarities
Belongs to the SEZ6 family.
Contains 2 CUB domains.
Contains 5 Sushi (CCP/SCR) domains. -
Post-translational
modificationsGlycosylated. -
Cellular localization
Cell membrane. Localized on dendrites and in the synaptic and postsynaptic fraction. - Information by UniProt
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Database links
- Entrez Gene: 539038 Cow
- Entrez Gene: 124925 Human
- SwissProt: A0JNA2 Cow
- SwissProt: Q53EL9 Human
- Unigene: 21837 Human
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Alternative names
- Brain-specific receptor-like protein C antibody
- BSRP-C antibody
- hSEZ-6 antibody
see all
Images
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ab121347 staining Sez6 in Mouse brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 4% serum for 1 hour at 4°C; antigen retrieval used 0.1% NaBh4. Samples were incubated with primary antibody (undiluted) for 24 hours at 4°C. An undiluted Cy3®-conjugated Goat anti-rabbit IgG polyclonal was used as the secondary antibody.
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ab121347, at 1/25, staining Sez6 in paraffin-embedded Human Hippocampus tissue by Immunohistochemistry.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab121347 has not yet been referenced specifically in any publications.