Anti-SFRS4/SRSF4 antibody (ab73893)
Key features and details
- Rabbit polyclonal to SFRS4/SRSF4
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-SFRS4/SRSF4 antibody
See all SFRS4/SRSF4 primary antibodies -
Description
Rabbit polyclonal to SFRS4/SRSF4 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Human SFRS4/SRSF4 (internal sequence).
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Positive control
- Extracts from LoVo cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, PBS
Without Mg2+ and Ca2+ -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab73893 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 57 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 57 kDa. |
Target
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Function
A probable role in alternative splice site selection during pre-mRNA splicing. -
Sequence similarities
Belongs to the splicing factor SR family.
Contains 2 RRM (RNA recognition motif) domains. -
Post-translational
modificationsExtensively phosphorylated on serine residues in the RS domain. -
Cellular localization
Nucleus speckle. - Information by UniProt
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Database links
- Entrez Gene: 6429 Human
- Entrez Gene: 57317 Mouse
- Omim: 601940 Human
- SwissProt: Q08170 Human
- SwissProt: Q8VE97 Mouse
- Unigene: 469970 Human
- Unigene: 2478 Mouse
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Alternative names
- arginine/serine-rich 4 antibody
- Pre mRNA splicing factor SRP75 antibody
- Pre-mRNA-splicing factor SRP75 antibody
see all
Images
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All lanes : Anti-SFRS4/SRSF4 antibody (ab73893) at 1/500 dilution
Lane 1 : extracts from LoVo cells
Lane 2 : extracts from LoVo cells with immunizing peptide at 5 µg
Lysates/proteins at 20 µg per lane.
Predicted band size: 57 kDa
Observed band size: 57 kDa
Additional bands at: 20 kDa, 48 kDa. We are unsure as to the identity of these extra bands.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab73893 has been referenced in 3 publications.
- Breitkopf SB et al. Serial-omics of P53-/-, Brca1-/- Mouse Breast Tumor and Normal Mammary Gland. Sci Rep 7:14503 (2017). PubMed: 29109428
- Guo H et al. Androgen receptor binding to an androgen-responsive element in the promoter of the Srsf4 gene inhibits its expression in mouse Sertoli cells. Mol Reprod Dev 82:976-85 (2015). PubMed: 26308373
- Gautrey HL & Tyson-Capper AJ Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells. PLoS One 7:e51497 (2012). WB ; Human . PubMed: 23284704