Mouse, Human Predicted to work with:
Rat, Cow, Dog, Pig, Chimpanzee
Recombinant fragment: MSGWADERGG EGDGRIYVGN LPTDVREKDL EDLFYKYGRI REIELKNRHG LVPFAFVRFE DPRDAEDAIY GRNGYDYGQC RLRVEFPRTY GGRGGWPRGG , corresponding to N terminal amino acids 1-101 of Human SFRS9 (NP_003760) linked to a proprietary tag.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 26 kDa.
Use at an assay dependent dilution.
FunctionPlays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.
Tissue specificityExpressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.
Sequence similaritiesBelongs to the splicing factor SR family. Contains 2 RRM (RNA recognition motif) domains.
Post-translational modificationsExtensively phosphorylated on serine residues in the RS domain.
Cellular localizationNucleus. Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.