Anti-SFTPA1 antibody - C-terminal (ab183085)

Overview

  • Product name
    Anti-SFTPA1 antibody - C-terminal
    See all SFTPA1 primary antibodies
  • Description
    Rabbit polyclonal to SFTPA1 - C-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human SFTPA1 aa 223-236 (C terminal). (NP_001087239)
    Sequence:

    YTNWYRGEPAGRGK


    Database link: Q8IWL2-2

  • Positive control
    • A549 cell lysate and Human fetal lung tissue lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.30
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol

    PBS without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab183085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 28 kDa.

Target

  • Function
    In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
  • Involvement in disease
    Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease.
    Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:267450]; also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Note=The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB.
  • Sequence similarities
    Belongs to the SFTPA family.
    Contains 1 C-type lectin domain.
    Contains 1 collagen-like domain.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix. Secreted > extracellular space > surface film.
  • Information by UniProt
  • Database links
  • Alternative names
    • 35 kDa pulmonary surfactant associated protein antibody
    • 35 kDa pulmonary surfactant-associated protein antibody
    • Alveolar proteinosis protein antibody
    • COLEC4 antibody
    • Collectin 4 antibody
    • Collectin-4 antibody
    • FLJ50593 antibody
    • FLJ51913 antibody
    • FLJ61144 antibody
    • FLJ77898, antibody
    • FLJ79095 antibody
    • FLJ99559 antibody
    • MGC133365 antibody
    • MGC198590 antibody
    • OTTHUMP00000019928 antibody
    • OTTHUMP00000019929 antibody
    • OTTHUMP00000019930 antibody
    • OTTHUMP00000019931 antibody
    • PSAP antibody
    • PSP A antibody
    • PSP-A antibody
    • PSPA antibody
    • pulmonary surfactant -associated protein, 35-KD antibody
    • pulmonary surfactant apoprotein PSP-A antibody
    • pulmonary surfactant associated protein A1 antibody
    • Pulmonary surfactant-associated protein A1 antibody
    • SFTA1_HUMAN antibody
    • SFTP1 antibody
    • SFTPA1 antibody
    • SFTPA1B antibody
    • SP A antibody
    • SP A1 antibody
    • SP-A antibody
    • SP-A1 antibody
    • SPA antibody
    • SPA1 antibody
    • surfactant protein A1 antibody
    • surfactant protein A1 variant AB'D' 6A2 antibody
    • surfactant protein A1 variant AB'D' 6A3 antibody
    • surfactant protein A1 variant AB'D' 6A4 antibody
    • surfactant protein A1 variant ACD' 6A2 antibody
    • surfactant protein A1 variant ACD' 6A3 antibody
    • surfactant protein A1 variant ACD' 6A4 antibody
    • surfactant protein A1 variant AD' 6A antibody
    • surfactant protein A1 variant AD' 6A2 antibody
    • surfactant protein A1 variant AD' 6A3 antibody
    • surfactant protein A1 variant AD' 6A4 antibody
    • surfactant protein A1B antibody
    • surfactant, pulmonary associated protein A1A antibody
    • surfactant, pulmonary associated protein A1B antibody
    • surfactant-associated protein, pulmonary 1 antibody
    see all

Images

  • All lanes : Anti-SFTPA1 antibody - C-terminal (ab183085) at 1/300 dilution

    Lane 1 : A549 cell lysate
    Lane 2 : Human fetal lung tissue lysate

    Lysates/proteins at 50 µg per lane.

    Secondary
    Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
    Developed using the ECL technique

    Predicted band size : 28 kDa


    Exposure time : 1 minute

References

ab183085 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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