Overview

  • Product name
  • Description
    Rabbit polyclonal to SGCE
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig, Xenopus laevis, Zebrafish
  • Immunogen

    Recombinant protein fragment, corresponding to a region within amino acids 1-232 of Human SGCE (UniProt ID: O43556).

  • Positive control
    • A549, HeLa, HepG2 and HCT116 cell lysates; Human ES2 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab155651 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 50 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Antigen retrieval also possible using Tris-EDTA buffer (pH8.0).

Target

  • Function
    Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
  • Tissue specificity
    Ubiquitous.
  • Involvement in disease
    Defects in SGCE are a cause of dystonia type 11 (DYT11) [MIM:159900]; also known as myoclonic dystonia or alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • Sequence similarities
    Belongs to the sarcoglycan alpha/epsilon family.
  • Cellular localization
    Cell membrane > sarcolemma. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • Database links
  • Alternative names
    • dystonia 11, myoclonic antibody
    • DYT11 antibody
    • Epsilon sarcoglycan antibody
    • Epsilon SG antibody
    • Epsilon-sarcoglycan antibody
    • Epsilon-SG antibody
    • ESG antibody
    • sarcoglycan, epsilon antibody
    • sgcE antibody
    • SGCE_HUMAN antibody
    see all

Images

  • Anti-SGCE antibody (ab155651) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size: 50 kDa



    10% SDS PAGE
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human ES2 xenograft tissue, labeling SGCE using ab155651 at a 1/100 dilution.

References

ab155651 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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