Overview

  • Product name
  • Description
    Rabbit polyclonal to SGPL1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to C-terminal residues of mouse SGPL1.

Properties

Applications

Our Abpromise guarantee covers the use of ab56183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 64 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
  • Tissue specificity
    Found in liver and kidney.
  • Pathway
    Lipid metabolism; sphingolipid metabolism.
  • Sequence similarities
    Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ13811 antibody
    • hSPL antibody
    • KIAA1252 antibody
    • S1P antibody
    • S1PL antibody
    • SGPL 1 antibody
    • SGPL1 antibody
    • SGPL1_HUMAN antibody
    • SP lyase antibody
    • SP-lyase 1 antibody
    • Sphingosine 1 phosphate aldolase antibody
    • Sphingosine 1 phosphate lyase 1 antibody
    • Sphingosine-1-phosphate aldolase antibody
    • Sphingosine-1-phosphate lyase 1 antibody
    • SPL 1 antibody
    • SPL antibody
    see all

References for Anti-SGPL1 antibody (ab56183)

This product has been referenced in:
  • Hagen N  et al. Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell Death Differ 18:1356-65 (2011). IHC (PFA fixed) ; Mouse . Read more (PubMed: 21331079) »

See 1 Publication for this product

Product Wall

Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step
Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 20°C
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: citrate buffer pH6
Sample
Mouse Tissue sections (skin)
Specification
skin
Permeabilization
No
Fixative
Formaldehyde
Username

Anabel Delagarza

Verified customer

Submitted Dec 18 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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