Overview

  • Product name
  • Description
    Goat polyclonal to SH2D1A/SAP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Pig, Macaque monkey
  • Immunogen

    Synthetic peptide:

    C-QYPVEKKSSARSTQ

    , corresponding to internal sequence amino acids 99-112 of Human SH2D1A/SAP

  • Positive control
    • Human Lymph Node lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab50422 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 0.6 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 14 kDa).

Target

  • Function
    Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
  • Tissue specificity
    Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.
  • Involvement in disease
    Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • Sequence similarities
    Contains 1 SH2 domain.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • DSHP antibody
    • Duncan disease SH2 protein antibody
    • Duncan disease SH2-protein antibody
    • EBVS antibody
    • IMD5 antibody
    • LYP antibody
    • MTCP1 antibody
    • SAP antibody
    • SAP/SH2D1A antibody
    • SH2 domain containing 1A antibody
    • SH2 domain protein 1A antibody
    • SH2 domain-containing protein 1A antibody
    • SH21A_HUMAN antibody
    • SH2D1A antibody
    • Signaling lymphocyte activation molecule associated protein antibody
    • Signaling lymphocytic activation molecule-associated protein antibody
    • SLAM associated protein antibody
    • SLAM associated protein/SH2 domain protein 1A antibody
    • SLAM-associated protein antibody
    • T cell signal transduction molecule SAP antibody
    • T-cell signal transduction molecule SAP antibody
    • XLP antibody
    • XLPD antibody
    see all

Images

References

ab50422 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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