Overview

  • Product nameAnti-SH2D4A antibody
    See all SH2D4A primary antibodies
  • Description
    Rabbit polyclonal to SH2D4A
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-454 of Human SH2D4A (NP_071354.2).

  • Positive control
    • Human pancreas and SH2D4A transfected 293T cell line lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab103166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 53 kDa.
IHC-P 1/200. PubMed: 24315626

Target

  • FunctionInhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
  • Tissue specificityUbiquitously expressed. Aberrantly expressed in some cancers.
  • Sequence similaritiesContains 1 SH2 domain.
  • Cellular localizationCytoplasm. Located at podocyte foot processes.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ20967 antibody
    • PPP1R38 antibody
    • Protein phosphatase 1 regulatory subunit 38 antibody
    • Protein SH antibody
    • Protein SH(2)A antibody
    • Protein SH2A antibody
    • SH2 domain containing 4A antibody
    • SH2 domain containing protein 4A antibody
    • SH2 domain-containing protein 4A antibody
    • SH24A_HUMAN antibody
    • SH2A antibody
    • Sh2d4a antibody
    see all

Anti-SH2D4A antibody images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of normal liver (left) and hepatocellular carcinoma (right) labelling SH2D4A with ab103166 at 1/200. Magnification: 400X. Representative pictures of different protein levels for SH2D4A.

  • Anti-SH2D4A antibody (ab103166) at 1/500 dilution + Human pancreas tissue lysate at 50 µg

    Predicted band size : 53 kDa
  • All lanes : Anti-SH2D4A antibody (ab103166) at 1/500 dilution

    Lane 1 : SH2D4A transfected 293T cell line lysate
    Lane 2 : Non transfected lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 53 kDa

References for Anti-SH2D4A antibody (ab103166)

This product has been referenced in:
  • Quagliata L  et al. SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. Eur J Cancer 50:731-8 (2014). IHC-P ; Human . Read more (PubMed: 24315626) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab103166.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"