The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 52 kDa (predicted molecular weight: 52 kDa).
FunctionInhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Tissue specificityUbiquitously expressed. Aberrantly expressed in some cancers.
Sequence similaritiesContains 1 SH2 domain.
Cellular localizationCytoplasm. Located at podocyte foot processes.