Overview

  • Product name
  • Description
    Goat polyclonal to SH3BP1
  • Host species
    Goat
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-PQPRPRSLASETN

    , corresponding to C terminal amino acids 689-701 of Human SH3BP1.

  • Positive control
    • Human spleen and tonsil tissues; Human brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab112005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 76 kDa. for 1 hr.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Function
    Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
  • Sequence similarities
    Contains 1 BAR domain.
    Contains 1 Rho-GAP domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3BP 1 antibody
    • 3BP-1 antibody
    • 3BP1_HUMAN antibody
    • ARHGAP43 antibody
    • dJ37E16 antibody
    • FLJ21318 antibody
    • OTTHUMP00000028981 antibody
    • SH3 domain binding protein 1 antibody
    • SH3 domain-binding protein 1 antibody
    • Sh3bp1 antibody
    see all

Images

  • ab112005, at 2.5µg/ml, staining SH3BP1 in formalin-fixed, paraffin-embedded Human Spleen tissue by Immunohistochemistry.
  • ab112005, at 2.5µg/ml, staining SH3BP1 in formalin-fixed, paraffin-embedded Human Tonsil tissue by Immunohistochemistry.
  • Anti-SH3BP1 antibody (ab112005) at 1 µg/ml + Human brain lysate (in RIPA buffer) at 35 µg

    Predicted band size: 76 kDa

References

ab112005 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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