FunctionBinds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Tissue specificityExpressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
Involvement in diseaseDefects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
Detection of SH3BP2 by Western Blot of Immunprecipitate.
ab117767 at 1µg/ml staining SH3BP2 in HeLa whole cell lysate immunoprecipitated using ab117767 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 10 seconds.
References for Anti-SH3BP2 antibody (ab117767)
has not yet been referenced specifically in any publications.
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