Overview

  • Product name
  • Description
    Rabbit polyclonal to SH3BP2
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 400-450 of Human SH3BP2 (NP_001116153.1).

  • Positive control
    • HeLa whole cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH: 7-8
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab117833 was affinity purified using an epitope specific to SH3BP2 immobilized on solid support.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab117833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
    • Tissue specificity
      Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
    • Involvement in disease
      Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
    • Sequence similarities
      Contains 1 PH domain.
      Contains 1 SH2 domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • 3BP-2 antibody
      • 3BP2 antibody
      • 3BP2_HUMAN antibody
      • Abl SH3 binding protein 2 antibody
      • Cherubism antibody
      • CRBM antibody
      • CRPM antibody
      • FLJ42079 antibody
      • FLJ54978 antibody
      • RES4-23 antibody
      • SH3 domain binding protein 2 antibody
      • SH3 domain-binding protein 2 antibody
      • Sh3bp2 antibody
      • TNFAIP3 interacting protein 2 antibody
      see all

    Images

    • Detection of Human SH3BP2 by Immunoprecipitation of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab117833 at 6 µg/mg of lysate. Subsequent WB detection was done using an other anti Human SH3BP2 antibody.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    References

    ab117833 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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