Overview

  • Product nameAnti-SH3BP4 antibody
    See all SH3BP4 primary antibodies
  • Description
    Rabbit polyclonal to SH3BP4
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to 18 amino acids near the C terminal end of Human SH3BP4 (NP_055336).

  • Positive control
    • Rat lung tissue lysate. Human lung tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (stable for up to 12 months).
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab106609 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 107 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionFunctions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis.
  • Tissue specificityExpressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
  • Sequence similaritiesContains 1 SH3 domain.
  • DomainThe SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity.
  • Post-translational
    modifications
    Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.
  • Cellular localizationMembrane > clathrin-coated pit. Cytoplasmic vesicle > clathrin-coated vesicle. Nucleus. Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BOG25 antibody
    • EH binding protein antibody
    • EH binding protein 10 antibody
    • EH-binding protein 10 antibody
    • EHB10 antibody
    • SH3 domain binding protein 4 antibody
    • SH3 domain-binding protein 4 antibody
    • SH3B4_HUMAN antibody
    • sh3bp4 antibody
    • Transferrin receptor trafficking protein antibody
    • Transferrin receptor-trafficking protein antibody
    • TTP antibody
    see all

Anti-SH3BP4 antibody images

  • Lane 1 : Anti-SH3BP4 antibody (ab106609) at 1 µg/ml
    Lane 2 : Anti-SH3BP4 antibody (ab106609) at 2 µg/ml

    Lane 1 : Rat lung tissue lysate
    Lane 2 : Rat lung tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 107 kDa
  • ab106609, at 5µg/ml, staining SH3BP4 in paraffin embedded Human lung tissue by Immunohistochemistry.

References for Anti-SH3BP4 antibody (ab106609)

ab106609 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting Abcam regarding our SH3BP4 antibodies.


Regarding ab106609, this antibody is specific for isoform 1.


The immunogen of antibody ab57005 shares 97% identity with the mouse and rat sequences, thus it is ...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"