Overview

  • Product nameAnti-SH3KBP1 antibody
    See all SH3KBP1 primary antibodies
  • Description
    Goat polyclonal to SH3KBP1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    VEAIVEFDYQAQH-C

    , corresponding to amino acids 2-14 of Human SH3KBP1 (NP_114098.1).

  • Positive control
    • human Placenta, Spleen and Tonsil tissues

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab118581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • FunctionAdapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis.
  • Tissue specificityUbiquitously expressed. Also expressed in some cancer cell lines.
  • Sequence similaritiesContains 3 SH3 domains.
  • DomainThe SH3 domains mediate interaction with SHKBP1.
  • Post-translational
    modifications
    Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
  • Cellular localizationCytoplasm > cytoskeleton. Cytoplasmic vesicle membrane. Cell junction > synapse > synaptosome. Cell junction > focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • c Cbl interacting protein antibody
    • Cbl interacting protein antibody
    • Cbl interacting protein of 85 kDa antibody
    • Cbl-interacting protein of 85 kDa antibody
    • CD2 binding protein 3 antibody
    • CD2-binding protein 3 antibody
    • CD2BP3 antibody
    • CIN 85 antibody
    • CIN85 antibody
    • GIG 10 antibody
    • GIG10 antibody
    • HSB 1 antibody
    • HSB-1 antibody
    • HSB1 antibody
    • Human Src family kinase binding protein 1 antibody
    • Human Src family kinase-binding protein 1 antibody
    • MIG 18 antibody
    • MIG18 antibody
    • Migration inducing gene 18 antibody
    • Migration inducing gene 18 protein antibody
    • SH3 domain kinase binding protein 1 antibody
    • SH3 domain-containing kinase-binding protein 1 antibody
    • SH3BP 1 antibody
    • SH3K1_HUMAN antibody
    • SH3KBP1 antibody
    • Src family kinase binding protein 1 antibody
    • src related kinase binding protein 1 antibody
    see all

Anti-SH3KBP1 antibody images

  • Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118581 at a concentration of 2.5 µg/ml.
  • Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118581 at a concentration of 2.5 µg/ml.
  • Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) using ab118581 at a concentration of 2.5 µg/ml.

References for Anti-SH3KBP1 antibody (ab118581)

ab118581 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"