Overview

  • Product nameAnti-SH3MD2 antibody
    See all SH3MD2 primary antibodies
  • Description
    Mouse monoclonal to SH3MD2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: LAQDAFHRKA SSLDSAVPIA PPPRQACSSL GPVLNESRPV VCERHRVVVS YPPQSEAELE LKEGDIVFVH KKREDGWFKG TLQRNGKTGL FPGSFVENI, corresponding to amino acids 790-889 of Human SH3MD2

Properties

Applications

Our Abpromise guarantee covers the use of ab57538 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceSH3MD2 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3MD2 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. There are two named isoforms.
    • Cellular localizationGolgi Apparatus. Lamellipodium. Perinuclear region of cytoplasm.
    • Database links
    • Alternative names
      • FLJ21602 antibody
      • KIAA1494 antibody
      • Plenty of SH3 domains antibody
      • Plenty of SH3s antibody
      • POSH antibody
      • Ring finger protein 142 antibody
      • RNF 142 antibody
      • RNF142 antibody
      • SH3 domain containing ring finger 1 antibody
      • SH3 domain containing RING finger protein 1 antibody
      • SH3 multiple domains 2 antibody
      • SH3RF1 antibody
      see all

    Anti-SH3MD2 antibody images



    • Predicted band size : 112 kDa
      SH3MD2 antibody (ab57538) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-SH3MD2 antibody (ab57538)

    ab57538 has not yet been referenced specifically in any publications.

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