• Product nameAnti-SH3PX1 antibody
    See all SH3PX1 primary antibodies
  • Description
    Rabbit polyclonal to SH3PX1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 260-534 of Human SH3PX1 (Q9Y5X1).

  • Positive control
    • H1299 and HCT116 whole cell lysates; Human Hepatoma tissue.



Our Abpromise guarantee covers the use of ab125906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 67 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionMay be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
  • Sequence similaritiesBelongs to the sorting nexin family.
    Contains 1 BAR domain.
    Contains 1 PX (phox homology) domain.
    Contains 1 SH3 domain.
  • DomainThe PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol-4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
  • Post-translational
    Ubiquitinated by ITCH.
    Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
  • Cellular localizationCytoplasmic vesicle membrane. Cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle. Golgi apparatus > trans-Golgi network. Cell projection > ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • MST 155 antibody
    • MST155 antibody
    • MSTP 155 antibody
    • MSTP155 antibody
    • OTTHUMP00000040083 antibody
    • Protein SDP 1 antibody
    • Protein SDP1 antibody
    • SDP 1 antibody
    • SDP1 antibody
    • SH3 and PX domain containing protein 3A antibody
    • SH3 and PX domain containing protein SH3PX1 antibody
    • SH3 and PX domain-containing protein 1 antibody
    • SH3 and PX domain-containing protein 3A antibody
    • SH3PX1 antibody
    • SH3PXD3A antibody
    • SNX 9 antibody
    • SNX9 antibody
    • SNX9_HUMAN antibody
    • Sorting nexin 9 antibody
    • Sorting nexin-9 antibody
    • WASP interactor protein antibody
    • Wiskott Aldrich syndrome protein (WASP) interactor protein antibody
    • Wiskott Aldrich syndrome protein interactor protein antibody
    • WISP antibody
    see all

Anti-SH3PX1 antibody images

  • All lanes : Anti-SH3PX1 antibody (ab125906) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HCT116 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 67 kDa
  • ab125906, at 1/500 dilution, staining SH3PX1 in Paraffin Embedded Human Hepatoma tissue by Immunohistochemistry.

References for Anti-SH3PX1 antibody (ab125906)

ab125906 has not yet been referenced specifically in any publications.

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