• Product nameAnti-SH3PX1 antibody
    See all SH3PX1 primary antibodies
  • Description
    Goat polyclonal to SH3PX1
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Dog, Xenopus laevis, Cynomolgus Monkey
  • Immunogen

    Synthetic peptide:


    , corresponding to internal sequence amino acids 510-522 of Human SH3PX1

  • Positive control
    • Human heart and human placenta lysates.


Associated products


Our Abpromise guarantee covers the use of ab45866 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesPeptide ELISA: Antibody detection limit dilution 1/1,000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 67 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
    • Sequence similaritiesBelongs to the sorting nexin family.
      Contains 1 BAR domain.
      Contains 1 PX (phox homology) domain.
      Contains 1 SH3 domain.
    • DomainThe PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol-4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
    • Post-translational
      Ubiquitinated by ITCH.
      Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
    • Cellular localizationCytoplasmic vesicle membrane. Cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle. Golgi apparatus > trans-Golgi network. Cell projection > ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • MST 155 antibody
      • MST155 antibody
      • MSTP 155 antibody
      • MSTP155 antibody
      • OTTHUMP00000040083 antibody
      • Protein SDP 1 antibody
      • Protein SDP1 antibody
      • SDP 1 antibody
      • SDP1 antibody
      • SH3 and PX domain containing protein 3A antibody
      • SH3 and PX domain containing protein SH3PX1 antibody
      • SH3 and PX domain-containing protein 1 antibody
      • SH3 and PX domain-containing protein 3A antibody
      • SH3PX1 antibody
      • SH3PXD3A antibody
      • SNX 9 antibody
      • SNX9 antibody
      • SNX9_HUMAN antibody
      • Sorting nexin 9 antibody
      • Sorting nexin-9 antibody
      • WASP interactor protein antibody
      • Wiskott Aldrich syndrome protein (WASP) interactor protein antibody
      • Wiskott Aldrich syndrome protein interactor protein antibody
      • WISP antibody
      see all

    Anti-SH3PX1 antibody images

    References for Anti-SH3PX1 antibody (ab45866)

    ab45866 has not yet been referenced specifically in any publications.

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