Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      C-HKGAIEKVKESDK
    • Amino acids
      510 to 522

Specifications

Our Abpromise guarantee covers the use of ab45878 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • MST 155
    • MST155
    • MSTP 155
    • MSTP155
    • OTTHUMP00000040083
    • Protein SDP 1
    • Protein SDP1
    • SDP 1
    • SDP1
    • SH3 and PX domain containing protein 3A
    • SH3 and PX domain containing protein SH3PX1
    • SH3 and PX domain-containing protein 1
    • SH3 and PX domain-containing protein 3A
    • SH3PX1
    • SH3PXD3A
    • SNX 9
    • SNX9
    • SNX9_HUMAN
    • Sorting nexin 9
    • Sorting nexin-9
    • WASP interactor protein
    • Wiskott Aldrich syndrome protein (WASP) interactor protein
    • Wiskott Aldrich syndrome protein interactor protein
    • WISP
    see all
  • Function
    May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
  • Sequence similarities
    Belongs to the sorting nexin family.
    Contains 1 BAR domain.
    Contains 1 PX (phox homology) domain.
    Contains 1 SH3 domain.
  • Domain
    The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol-4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
  • Post-translational
    modifications
    Ubiquitinated by ITCH.
    Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
  • Cellular localization
    Cytoplasmic vesicle membrane. Cell membrane. Cytoplasmic vesicle > clathrin-coated vesicle. Golgi apparatus > trans-Golgi network. Cell projection > ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
  • Information by UniProt

References

ab45878 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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