• Product name
  • Description
    Rabbit polyclonal to SH3TC2
  • Specificity
    ab111197 detects endogenous levels of total SH3TC2 protein.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal region of Human SH3TC2.

  • Positive control
    • Human brain tissue.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 0.88% Sodium chloride, 49.1% PBS
    Note: PBS (without Mg2+ and Ca2+)
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab111197 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab111197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Tissue specificity
    Strongly expressed in brain and spinal cord. Expressed at equal level in spinal cord and sciatic nerve. Weakly expressed in striated muscle.
  • Involvement in disease
    Defects in SH3TC2 are the cause of Charcot-Marie-Tooth disease type 4C (CMT4C) [MIM:601596]. CMT4C is a recessive form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. CMT4C is characterized by onset in childhood, early-onset scoliosis and a distinct Schwann cell pathology.
    Defects in SH3TC2 are the cause of mononeuropathy of the median nerve mild (MNMN) [MIM:613353]. A disease characterized by median nerve mononeuropathy at the wrist. The clinical presentation ranges from a mild phenotype, consistent with carpal tunnel syndrome, to a severe median nerve mononeuropathy at the wrist associated with evidence of a more widespread axonal polyneuropathy. The latter phenotype is similar to that of patients with hereditary neuropathy with liability to pressure palsies.
  • Sequence similarities
    Contains 1 SH3 domain.
    Contains 8 TPR repeats.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMT4C antibody
    • D430044G18Rik antibody
    • FLJ13605 antibody
    • KIAA1985 antibody
    • MNMN antibody
    • PP12494 antibody
    • RGD1309038 antibody
    • S3TC2_HUMAN antibody
    • SH3 domain and tetratricopeptide repeats-containing protein 2 antibody
    • SH3TC2 antibody
    see all

Anti-SH3TC2 antibody images

  • ab111197 at 1/50 dilution staining SH3TC2 in paraffin-embedded Human Brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

References for Anti-SH3TC2 antibody (ab111197)

This product has been referenced in:
  • Vijay S  et al. Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-a6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C. Biochim Biophys Acta 1862:1279-90 (2016). Read more (PubMed: 27068304) »

See 1 Publication for this product

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Immunocytochemistry/ Immunofluorescence
Rabbit Cell (Sciatic nerve, teased fibers, spinal cord)
Yes - acetone
Sciatic nerve, teased fibers, spinal cord
Blocking step
5%BSA+ 0.5% Triton-X as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

Abcam user community

Verified customer

Submitted Jun 14 2017

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The amino acid range for this immunogen is aa#380-430 of human SH3TC2 with acc#Q8TF17 (http://www.uniprot.org/uniprot/Q8TF17). This antibody will bind to isoform 1 based on prediction. It will not bind to isoforms ...

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Expiration date: 15/04/2013

Value: £227.00

I am very pleased to hear you would like to accept our offer and test ab111197 in WB with HeLa cells. This code will give you £22...

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As long as one of the parameters to be tested (applications or species) is already stated on the datasheet, the Abreview system is elegible.

In this case, if you wish to test the antibody in WB, please make...

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Thank you for contacting us.

According to the expression profile of this protein it shows a moderate pattern in brain tissues:


The antibody ab111197 detects the endogenous protei...

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