Overview

  • Product name
  • Description
    Rabbit polyclonal to SHANK2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human SHANK2 aa 886-916 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9UPX8

  • Positive control
    • Mouse bladder tissue lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab171189 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab171189 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 159 kDa.

Target

  • Function
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • Tissue specificity
    Expressed in epithelial cells (at protein level). All isoforms except isoform 7 are expressed predominantly in brain, with highest levels in olfactory bulb, cerebral cortex, cerebellum, central gray matter and hippocampus. Moderate levels of expression are seen in the caudate putamen, thalamic nuclei and brain stem. In cerebellum primarily expressed in Purkinje cells. Isoform 7 is not expressed in brain but expressed in liver, cholangiocytes and thymus. Isoform 7 is present in pancreas, colonic mucosa and thymocytes (at protein level).
  • Sequence similarities
    Belongs to the SHANK family.
    Contains 1 PDZ (DHR) domain.
    Contains 1 SAM (sterile alpha motif) domain.
    Contains 1 SH3 domain.
  • Developmental stage
    Expressed during early postnatal brain development, especially in the caudate putamen and thalamic nuclei. Expression in the cerebral cortex, the hippocampus and the cerebellum is moderate to high at P5 and shows a stable expression throughout development. Isoforms 1, 2, 4 and 6 are predominantly expressed in cerebellum up to the age of approximately 3 weeks. Isoform 1 expression decreases during development of cortex but slightly increases in cerebellum.
  • Domain
    The PDZ domain is required for interaction with GRID2, PLCB3, SLC9A3 and CFTR.
  • Cellular localization
    Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Present in the dendritic spines of cerebellar Purkinje cells (By similarity). Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • AUTS17 antibody
    • Cortactin binding protein 1 antibody
    • Cortactin SH3 domain-binding protein antibody
    • Cortactin-binding protein 1 antibody
    • CortBP1 antibody
    • CTTNBP1 antibody
    • GKAP/SAPAP interacting protein antibody
    • GKAP/SAPAP-interacting protein antibody
    • KIAA1022 antibody
    • Proline rich synapse associated protein 1 antibody
    • Proline-rich synapse-associated protein 1 antibody
    • ProSAP1 antibody
    • SH3 and multiple ankyrin repeat domains 2 antibody
    • SH3 and multiple ankyrin repeat domains protein 2 antibody
    • SHAN2_RAT antibody
    • SHANK antibody
    • Shank2 antibody
    • SPANK-3 antibody
    see all

Images

  • Anti-SHANK2 antibody (ab171189) at 1/100 dilution + Mouse bladder tissue lysate at 35 µg

    Predicted band size : 159 kDa

References

ab171189 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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