FunctionMay have a role in normal immune development and control of inflammation.
Tissue specificityHighly expressed in skeletal muscle and placenta and at lower levels in brain, heart, colon without mucosa, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
ab125188, at 6 µg/mg lysate, detecting SHARPIN in HeLa cell lysate (1 mg of immunoprecipitate, 20% loaded in the lane) by Immunoprecipitation. For the subsequent Western blot, ab125188 was used at 1 µg/ml. The blot was developed using the ECL technique, with an exposure time of 30 seconds.
References for Anti-SHARPIN antibody (ab125188)
This product has been referenced in:
Yang Y et al. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Discov4:480-93 (2014).
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