Overview

  • Product nameAnti-SHB antibody
    See all SHB primary antibodies
  • Description
    Rabbit polyclonal to SHB
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the N terminal region of human SHB

  • Positive control
    • Human lung carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab80239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
IHC-P 1/10 - 1/50.

Target

  • FunctionAdapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • Tissue specificityWidely expressed.
  • Sequence similaritiesContains 1 SH2 domain.
  • DomainThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • Post-translational
    modifications
    Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • Cellular localizationCytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • bA3J10.2 antibody
    • OTTHUMP00000021397 antibody
    • RP11 3J10.8 antibody
    • RP113J10.8 antibody
    • SH2 domain containing adapter protein B antibody
    • SH2 domain-containing adapter protein B antibody
    • SHB (Src homology 2 domain containing) adaptor protein B antibody
    • SHB adaptor protein (a Src homology 2 protein) antibody
    • SHB adaptor protein antibody
    • Shb antibody
    • SHB_HUMAN antibody
    • Src homology 2 domain containing adaptor protein B antibody
    • Src homology 2 protein antibody
    see all

Anti-SHB antibody images

  • ab80239, at a 1/10 dilution, staining SHB in formalin fixed, paraffin embedded human lung carcinoma tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was used, followed by DAB staining.

References for Anti-SHB antibody (ab80239)

ab80239 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"