The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10 - 1/50.
FunctionAdapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Tissue specificityWidely expressed.
Sequence similaritiesContains 1 SH2 domain.
DomainThe SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
Post-translational modificationsPhosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
Cellular localizationCytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
ab80239, at a 1/10 dilution, staining SHB in formalin fixed, paraffin embedded human lung carcinoma tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was used, followed by DAB staining.
References for Anti-SHB antibody (ab80239)
has not yet been referenced specifically in any publications.
Publishing research using ab80239? Please let us know so that we can cite the reference in this datasheet.
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