Overview

  • Product nameAnti-SHC4 (phospho) antibody
    See all SHC4 primary antibodies
  • Description
    Rabbit polyclonal to SHC4 (phospho)
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 352-609 of Human SHC4 (NP_976224).

  • Positive control
    • MOLT4 whole cell lysate; A431 lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab96182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 69 kDa.

Target

  • FunctionActivates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
  • Tissue specificityOnly expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
  • Sequence similaritiesContains 1 PID domain.
    Contains 1 SH2 domain.
  • Post-translational
    modifications
    Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2.
  • Cellular localizationCell junction > synapse > postsynaptic cell membrane. Colocalized with MUSK at the neuromuscular junction.
  • Information by UniProt
  • Database links
  • Alternative names
    • hShcD antibody
    • MGC34023 antibody
    • Rai like protein antibody
    • Rai-like protein antibody
    • RaLP antibody
    • SH2 domain protein C4 antibody
    • SHC (Src homology 2 domain containing) family member 4 antibody
    • SHC 4 antibody
    • SHC antibody
    • SHC family member 4 antibody
    • SHC transforming protein 4 antibody
    • SHC transforming protein D antibody
    • SHC-transforming protein 4 antibody
    • SHC-transforming protein D antibody
    • Shc4 antibody
    • SHC4_HUMAN antibody
    • SHCD antibody
    • Src homology 2 domain containing family member 4 antibody
    • Src homology 2 domain containing transforming protein C4 antibody
    • Src homology 2 domain-containing-transforming protein C4 antibody
    see all

Anti-SHC4 (phospho) antibody images

  • Anti-SHC4 (phospho) antibody (ab96182) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 69 kDa

References for Anti-SHC4 (phospho) antibody (ab96182)

ab96182 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"