Overview

  • Product nameAnti-SHFM3 antibody
    See all SHFM3 primary antibodies
  • Description
    Rabbit polyclonal to SHFM3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 334-383 (STFYCLQTDG NHLLATGSSY YGLVRLWDRR QRACLHAFPL TSTPLSSPVY) of Rat SHFM3 (NP_001101070).

  • Positive control
    • Rat Muscle Lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab111916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml. Predicted molecular weight: 46 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionProbably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.
  • Tissue specificityExpressed in brain, kidney, lung and liver.
  • Involvement in diseaseDefects in FBXW4 are a cause of split-hand/foot malformation type 3 (SHFM3) [MIM:246560]. SHFM3 is an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.
  • Sequence similaritiesContains 1 F-box domain.
    Contains 4 WD repeats.
  • Information by UniProt
  • Database links
  • Alternative names
    • DAC antibody
    • Dactylin antibody
    • F box and WD 40 domain containing protein 4 antibody
    • F box and WD 40 domain protein 4 antibody
    • F box and WD repeat domain containing 4 antibody
    • F box/WD repeat containing protein 4 antibody
    • F box/WD repeat protein 4 antibody
    • F-box and WD-40 domain-containing protein 4 antibody
    • F-box/WD repeat-containing protein 4 antibody
    • FBW 4 antibody
    • FBW4 antibody
    • FBWD 4 antibody
    • FBWD4 antibody
    • FBXW 4 antibody
    • FBXW4 antibody
    • FBXW4_HUMAN antibody
    • OTTHUMP00000059175 antibody
    • SHFM 3 antibody
    • SHSF 3 antibody
    • SHSF3 antibody
    • Split hand/foot malformation (ectrodactyly) type antibody
    see all

Anti-SHFM3 antibody images

  • Anti-SHFM3 antibody (ab111916) at 1 µg/ml + Rat Muscle Lysate at 10 µg

    Predicted band size : 46 kDa

References for Anti-SHFM3 antibody (ab111916)

ab111916 has not yet been referenced specifically in any publications.

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