Overview

  • Product name
    Anti-Shoc2 / Sur8 antibody
    See all Shoc2 / Sur8 primary antibodies
  • Description
    Rabbit polyclonal to Shoc2 / Sur8
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the N terminus of human Shoc2/ Sur8.

Properties

  • Form
    Lyophilised:Reconstitute in 200ul distilled water.
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: None
    Constituents: Whole serum
  • Concentration information loading...
  • Purity
    Whole antiserum
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab100937 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 65 kDa.
ELISA Use at an assay dependent dilution.

Target

  • Function
    Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
  • Involvement in disease
    Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) [MIM:607721]. NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
  • Sequence similarities
    Belongs to the SHOC2 family.
    Contains 20 LRR (leucine-rich) repeats.
  • Cellular localization
    Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0862 antibody
    • Leucine-rich repeat protein SHOC-2 antibody
    • Protein soc-2 homolog antibody
    • Protein Sur-8 homolog antibody
    • Ras-binding protein Sur-8 antibody
    • SHOC2 antibody
    • SHOC2_HUMAN antibody
    see all

References

ab100937 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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