Anti-Shoc2 / Sur8 antibody - N-terminal (ab177927)

Overview

  • Product name
    Anti-Shoc2 / Sur8 antibody - N-terminal
    See all Shoc2 / Sur8 primary antibodies
  • Description
    Rabbit polyclonal to Shoc2 / Sur8 - N-terminal
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide within Human Shoc2/ Sur8 aa 76-125 (N terminal). The exact sequence is proprietary. NP_031399
    Sequence:

    NPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQL


    Database link: Q9UQ13

  • Positive control
    • Human fetal kidney lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Constituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab177927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 64 kDa.

Target

  • Function
    Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.
  • Involvement in disease
    Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) [MIM:607721]. NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.
  • Sequence similarities
    Belongs to the SHOC2 family.
    Contains 20 LRR (leucine-rich) repeats.
  • Cellular localization
    Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus upon growth factor stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0862 antibody
    • Leucine-rich repeat protein SHOC-2 antibody
    • Protein soc-2 homolog antibody
    • Protein Sur-8 homolog antibody
    • Ras-binding protein Sur-8 antibody
    • SHOC2 antibody
    • SHOC2_HUMAN antibody
    see all

Images

  • Anti-Shoc2 / Sur8 antibody - N-terminal (ab177927) at 1 µg/ml + Human fetal kidney lysate at 10 µg

    Predicted band size : 64 kDa

References

ab177927 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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