Overview

  • Product nameAnti-SHOX antibody
    See all SHOX primary antibodies
  • Description
    Mouse polyclonal to SHOX
  • SpecificityThis antibody is reactive against mammalian transfected lysate.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    SHOX (NP_006874.1, 1 a.a. ~ 225 a.a) full-length human protein.

  • Positive control
    • SHOX transfected 293T cell lysate and human liver tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/500 - 1/1000. Detects bands of approximately 30 and 36 kDa (predicted molecular weight: 32 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionControls fundamental aspects of growth and development.
    • Tissue specificitySHOXA is expressed in skeletal muscle, placenta, pancreas, heart and bone marrow fibroblast and SHOXB is highly expressed in bone marrow fibroblast followed by kidney and skeletal muscle. SHOXB is not expressed in brain, kidney, liver and lung. Highly expressed in osteogenic cells.
    • Involvement in diseaseDefects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD) [MIM:127300]. LWD is a dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna.
      Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD) [MIM:249700]. LMD is an autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date.
      Defects in SHOX are a cause of idiopathic short stature (ISS) [MIM:300582]. Idiopathic short stature is usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of national height standards in the absence of specific causative disorders.
    • Sequence similaritiesBelongs to the paired homeobox family. Bicoid subfamily.
      Contains 1 homeobox DNA-binding domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • GCFX antibody
      • Growth control factor, X linked antibody
      • Homo sapiens shox gene, alternatively spliced products, complete cds antibody
      • PHOG antibody
      • Pseudoautosomal homeobox containing osteogenic antibody
      • Pseudoautosomal homeobox containing osteogenic protein antibody
      • Pseudoautosomal homeobox-containing osteogenic protein antibody
      • Short stature homeobox antibody
      • Short stature homeobox containing protein antibody
      • Short stature homeobox protein antibody
      • Short stature homeobox-containing protein antibody
      • SHOX antibody
      • SHOX_HUMAN antibody
      • SHOXY antibody
      • SS antibody
      • Turner syndrome antibody
      see all

    Anti-SHOX antibody images

    • Anti-SHOX antibody (ab67927) at 1/500 dilution + human liver tissue lysate at 25 µg

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 32 kDa
      Observed band size : 36 kDa (why is the actual band size different from the predicted?)
    • All lanes : Anti-SHOX antibody (ab67927) at 1/500 dilution

      Lane 1 : SHOX transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 32 kDa
      Observed band size : 30 kDa (why is the actual band size different from the predicted?)

    References for Anti-SHOX antibody (ab67927)

    ab67927 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab67927.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"