• Product nameAnti-SHP1 antibody [M160]
    See all SHP1 primary antibodies
  • Description
    Mouse monoclonal [M160] to SHP1
  • Specificityab76202 does not cross-react with SHP2.
  • Tested applicationsSuitable for: WB, IP, ELISA, ICCmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant protein containing amino acids in the C terminal region of human SHP1.

  • Positive control
    • Jurkat cells treated with pervanadate (1 mM) for 30 min.



Our Abpromise guarantee covers the use of ab76202 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
IP 1/100.
ELISA 1/2000.
ICC 1/100.


  • FunctionPlays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • Tissue specificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • Post-translational
    Phosphorylated on serine and tyrosine residues.
  • Cellular localizationCytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
  • Information by UniProt
  • Database links
  • Alternative names
    • 70Z-SHP antibody
    • EC antibody
    • HCP antibody
    • HCPH antibody
    • Hematopoietic cell phosphatase antibody
    • Hematopoietic cell protein tyrosine phosphatase antibody
    • Hematopoietic cell protein-tyrosine phosphatase antibody
    • HPTP1C antibody
    • Protein tyrosine phosphatase 1C antibody
    • Protein tyrosine phosphatase non receptor type 6 antibody
    • Protein tyrosine phosphatase SHP1 antibody
    • Protein-tyrosine phosphatase 1C antibody
    • protein-tyrosine phosphatase SHP 1 antibody
    • Protein-tyrosine phosphatase SHP-1 antibody
    • PTN6_HUMAN antibody
    • PTP 1C antibody
    • PTP-1C antibody
    • PTP1C antibody
    • Ptpn6 antibody
    • SH PTP 1 antibody
    • SH PTP1 antibody
    • SH-PTP1 antibody
    • SHP 1 antibody
    • SHP 1L antibody
    • SHP1 antibody
    • SHP1L antibody
    • tyrosine protein phosphatase non receptor type 6 antibody
    • Tyrosine-protein phosphatase non-receptor type 6 antibody
    see all

Anti-SHP1 antibody [M160] images

  • All lanes : Anti-SHP1 antibody [M160] (ab76202) at 1/500 dilution

    Lane 1 : Jurkat cells treated with pervanadate (1 mM) for 30 min
    Lane 2 : Jurkat cells treated with pervanadate (1 mM) for 30 min and treated with lambda phosphatase

    Predicted band size : 68 kDa
    Observed band size : 68 kDa

References for Anti-SHP1 antibody [M160] (ab76202)

ab76202 has not yet been referenced specifically in any publications.

Product Wall

Abcam has not validated the combination of species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - whole cell (Differentiated 3T3-L1 adipocytes)
Gel Running Conditions Reduced Denaturing (8.5%)
Loading amount 30 µg
Treatment Transfected with scramble or Shp1 shRNA
Specification Differentiated 3T3-L1 adipocytes
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

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Submitted Aug 30 2016